| Responsabile scientifico:
Prof. Giuseppe AMBROSIO Personale afferente:
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Dove siamo
Blocco C piano 2, Piazzale Giorgio Menghini, 3, 06129 Perugia PG, Italy
Cosa facciamo
| Infiammazione e risposte del sistema immunitario (Isabella TRITTO) |
| Studio delle conseguenze infiammatorie dello stress ossidativo e del danno da ischemia e riperfusione a livello cardiaco e vascolare. |
| Prevenzione e sanità pubblica (Giuseppe AMBROSIO) |
| Valutazione dell’impatto della organizzazione sanitaria sugli outcome delle malattie cardiovascolari, e sul COVID-19. |
| Malattie cardiovascolari (Erberto CARLUCCIO) |
| Imaging avanzato dello scompenso cardiaco; farmacoterapia dello scompenso cardiaco. |
| Malattie cardiovascolari (Giuseppe AMBROSIO) |
| Fisiopatologia, clinica, e terapia della cardiopatia ischemica |
La Gestione della Pandemia e delle sue conseguenze (Giuseppe AMBROSIO)  |
| Analisi a livello mondiale dell'impatto del COVID sui ricoveri ospedalieri per sindrome coronarica acuta; Analisi a livello multinazionale della mortalità/morbilità durante pandemia COVID; Valutazione a livello nazionale dell'impatto della pandemia COVID sulla prevenzione cardiovascolare; COVID e scompenso cardiaco. |
Tecnologie e Strumentazione
| Pre-Clinical Models |
| Isolated organs, in vivo videomicroscopy, Set-up for organ perfusion. |
| Videomicroscope equipped with visible and UV light and TV chain. |
| Clinical Trial |
| Advanced software for echocardiography images Ambrosio. |
Pubblicazioni
Tricoci P, et al. Thrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes. New England Journal of Medicine 366:20-33, 2012
Newman MF, et al. Effect of adenosine-regulating agent acadesine on morbidity and mortality associated with coronary artery bypass grafting: the RED-CABG randomized controlled trial. JAMA – Journal of the American Medical Association 308:157-64, 2012.
Senni M, et al. New strategies for heart failure with preserved ejection fraction: the importance of targeted therapies for heart failure phenotypes. European Heart Journal 35:2797-815, 2014.
Reyes LA, et al. Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart. Proceedings of the National Academy of Sciences U S A. 112:11648-53, 2015.
Verheugt FWA, et al GARFIELD-AF Investigators. Characteristics of patients with atrial fibrillation prescribed antiplatelet monotherapy compared with those on anticoagulants: insights from the GARFIELD-AF registry. European Heart Journal 39:464-473, 2018.
Simonovic D, et al. Exercise elicits dynamic changes in extravascular lung water and haemodynamic congestion in heart failure patients with preserved ejection fraction. European Journal of Heart Failure, 20:1366-1369, 2018.
Carluccio E, et al. Superior Prognostic Value of Right Ventricular Free Wall Compared to Global Longitudinal Strain in Patients With Heart Failure. JASE – Journal of the American Society of Echocardiography 32:836-844, 2019.
Cimmino G, et al. Oxidized Low-Density Lipoproteins Induce Tissue Factor Expression in T-Lymphocytes via activation of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1. Cardiovascular Research 116:1125-1135, 2020.
Achilleos S, et al, C-MOR consortium. Excess all-cause mortality and COVID-19-related mortality: a temporal analysis in 22 countries, from January until August 2020. International Journal of Epidemioliogy 2022 Feb 18;51(1):35-53.
Rosano GMC, et al. AIFA Registry Group. Impact of the COVID-19 pandemic on prescription of sacubitril/valsartan in Italy. Eur J Heart Fail. 2022 May;24(5):855-860
Pallari CT, Achilleos S, Quattrocchi A, Gabel J, Critselis E, Athanasiadou M, Rahmanian Haghighi MR, Papatheodorou S, Liu T, Artemiou A, Rodriguez-Llanes JM, Bennett CM, Zimmermann C, Schernhammer E, Bustos Sierra N, Ekelson R, Lobato J, Macedo L, Mortensen LH, Critchley J, Goldsmith L, Denissov G, Le Meur N, Kandelaki L, Athanasakis K, Binyaminy B, Maor T, Stracci F, Ambrosio G, Davletov K, Glushkova N, Martial C, Chan Sun M, Hagen TP, Chong M, Barron M, Łyszczarz B, Erzen I, Arcos Gonzalez P, Burström B, Pidmurniak N, Verstiuk O, Huang Q, Polemitis A, Charalambous A, Demetriou CA. Magnitude and determinants of excess total, age-specific and sex-specific all-cause mortality in 24 countries worldwide during 2020 and 2021: results on the impact of the COVID-19 pandemic from the C-MOR project. BMJ Glob Health. 2024 Apr 18;9(4):e013018. doi: 10.1136/bmjgh-2023-013018. PMID: 38637119; PMCID: PMC11029481
Stracci F, Gili A, Caruso E, Polosa R, Ambrosio G. Value of hospital datasets of COVID-19 patients across different pandemic periods: challenges and opportunities. Intern Emerg Med. 2023 Jun;18(4):969-971. doi: 10.1007/s11739-022-03162-y. Epub 2023 Jan 2. Erratum in: Intern Emerg Med. 2023 Nov 1;: PMID: 36592272; PMCID: PMC9807090.