Chi siamo
Responsabile scientifico: Prof.ssa Luigina ROMANI Personale afferente:
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Dove siamo
Edificio C piano 4, P.zza Lucio Severi, 1 Sant’Andrea delle Fratte 06129 Perugia, Italy
Cosa facciamo
Infiammazione e risposte del sistema immunitario (Marina Maria BELLET/Emanuela ROSATI) |
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Interazione ospite/microbioma (Claudio COSTANTINI) |
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Terapie innovative (Giorgia RENGA) |
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Malattie rare (Marilena PARIANO) |
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Scienze Omiche Integrate alla Medicina di Precisione (Marina Maria BELLET) |
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Strumenti Innovativi e Nuove Tecnologie per la Tutela della Salute (Marina Maria BELLET) |
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Tecnologie e Strumentazione
Genomics Metagenomics |
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Proteomics and Metabolomics |
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Target Identification and Validation |
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Pre-Clinical Models |
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Pubblicazioni
Costantini C, Nunzi E, Spolzino A, Merli F, Facchini L, Spadea A, Melillo L, Codeluppi K, Marchesi F, Marchesini G, Valente D, Dragonetti G, Nadali G, Englmaier L, Coufalikova K, Spáčil Z, Bellet MM, Pariano M, Renga G, Stincardini C, D'Onofrio F, Bozza S, Pagano L, Aversa F, Romani L. A High-Risk Profile for Invasive Fungal Infections Is Associated with Altered Nasal Microbiota and Niche Determinants. Infect Immun. 2022 Apr 21;90(4):e0004822. doi: 10.1128/iai.00048-22. Epub 2022 Mar 21. PMID: 35311544; PMCID: PMC9022527.
Renga G, Nunzi E, Pariano M, Puccetti M, Bellet MM, Pieraccini G, D'Onofrio F, Santarelli I, Stincardini C, Aversa F, Riuzzi F, Antognelli C, Gargaro M, Bereshchenko O, Ricci M, Giovagnoli S, Romani L, Costantini C. Optimizing therapeutic outcomes of immune checkpoint blockade by a microbial tryptophan metabolite. J Immunother Cancer. 2022 Mar;10(3):e003725. doi: 10.1136/jitc-2021-003725. PMID: 35236743; PMCID: PMC8896050.
van de Veerdonk FL, Renga G, Pariano M, Bellet MM, Servillo G, Fallarino F, De Luca A, Iannitti RG, Piobbico D, Gargaro M, Manni G, D'Onofrio F, Stincardini C, Sforna L, Borghi M, Castelli M, Pieroni S, Oikonomou V, Villella VR, Puccetti M, Giovagnoli S, Galarini R, Barola C, Maiuri L, Della Fazia MA, Cellini B, Talesa VN, Dinarello CA, Costantini C, Romani L. Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy. J Clin Invest. 2022 Jan 18;132(2):e144983. doi: 10.1172/JCI144983. PMID: 34847078; PMCID: PMC8759782.
Costantini C, Nunzi E, Spolzino A, Palmieri M, Renga G, Zelante T, Englmaier L, Coufalikova K, Spáčil Z, Borghi M, Bellet MM, Acerbi E, Puccetti M, Giovagnoli S, Spaccapelo R, Talesa VN, Lomurno G, Merli F, Facchini L, Spadea A, Melillo L, Codeluppi K, Marchesi F, Marchesini G, Valente D, Dragonetti G, Nadali G, Pagano L, Aversa F, Romani L. Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients. Infect Immun. 2021 Jul 15;89(8):e0010521. doi: 10.1128/IAI.00105-21. Epub 2021 Jul 15. PMID: 33782152; PMCID: PMC8281212.
Bellet MM, Stincardini C, Costantini C, Gargaro M, Pieroni S, Castelli M, Piobbico D, Sassone-Corsi P, Della-Fazia MA, Romani L, Servillo G. The Circadian Protein PER1 Modulates the Cellular Response to Anticancer Treatments. Int J Mol Sci. 2021 Mar 15;22(6):2974. doi: 10.3390/ijms22062974. PMID: 33804124; PMCID: PMC8001324.
Renga G, Bellet MM, Pariano M, Gargaro M, Stincardini C, D'Onofrio F, Mosci P, Brancorsini S, Bartoli A, Goldstein AL, Garaci E, Romani L, Costantini C. Thymosin α1 protects from CTLA-4 intestinal immunopathology. Life Sci Alliance. 2020 Aug 14;3(10):e202000662. doi: 10.26508/lsa.202000662. PMID: 32817121; PMCID: PMC7441522.
De Falco F, Del Papa B, Baldoni S, Sabatini R, Falzetti F, Di Ianni M, Martelli MP, Mezzasoma F, Pelullo M, Marconi P, Sportoletti P, Screpanti I, Rosati E. IL-4-dependent Jagged1 expression/processing is associated with survival of chronic lymphocytic leukemia cells but not with Notch activation. Cell Death Dis. 2018 Nov 26;9(12):1160. doi: 10.1038/s41419-018-1185-6. PMID:
30478302; PMCID: PMC6255763.
Renga G, Moretti S, Oikonomou V, Borghi M, Zelante T, Paolicelli G, Costantini C, De Zuani M, Villella VR, Raia V, Del Sordo R, Bartoli A, Baldoni M, Renauld JC, Sidoni A, Garaci E, Maiuri L, Pucillo C, Romani L. IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut. Cell Rep. 2018 May 8;23(6):1767-1778. doi: 10.1016/j.celrep.2018.04.034. PMID: 29742432; PMCID: PMC5976578.
Romani L, Oikonomou V, Moretti S, Iannitti RG, D'Adamo MC, Villella VR, Pariano M, Sforna L, Borghi M, Bellet MM, Fallarino F, Pallotta MT, Servillo G, Ferrari E, Puccetti P, Kroemer G, Pessia M, Maiuri L, Goldstein AL, Garaci E. Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis. Nat Med. 2017 May;23(5):590-600. doi: 10.1038/nm.4305. Epub 2017 Apr 10. Erratum in: Nat Med. 2018 Sep;24(9):1481. Erratum in: Nat Med. 2018 Sep;24(9):1482. PMID: 28394330; PMCID: PMC5420451.
Moretti S, Renga G, Oikonomou V, Galosi C, Pariano M, Iannitti RG, Borghi M, Puccetti M, De Zuani M, Pucillo CE, Paolicelli G, Zelante T, Renauld JC, Bereshchenko O, Sportoletti P, Lucidi V, Russo MC, Colombo C, Fiscarelli E, Lass-Flörl C, Majo F, Ricciotti G, Ellemunter H, Ratclif L, Talesa VN, Napolioni V, Romani L. A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis. Nat Commun. 2017 Jan 16;8:14017. doi: 10.1038/ncomms14017. PMID: 28090087; PMCID: PMC5241810.
Renga G, et al. Bridging of host-microbiota tryptophan partitioning by the serotonin pathway in fungal pneumonia. Nat Commun. 2023 Sep 16;14(1):5753. doi: 10.1038/s41467-023-41536-8.
Stincardini C, et al. The circadian control of tryptophan metabolism regulates the host response to pulmonary fungal infections. PNAS Nexus. 2023 Feb 3;2(3):pgad036. doi: 10.1093/pnasnexus/pgad036.