Research Topics

Details
  • Clinical and biological studies on aging; identification of biomarkers of aging and relationship to frailty, both physical and cognitive, and major chronic diseases of the elderly (cognitive disorders, metabolic disorders, osteoporosis); development of clinical trials with natural molecules or drugs for prevention and treatment of age-related diseases. (Professor Patrizia Mecocci);
  • Diagnosis and biopathological characterization of major human malignancies, with particular reference to lung and breast cancer, by traditional, histochemical, immunohistochemical and in situ hybridization methods. Translational research on prognostic and predictive factors of response to therapy mainly for lung and breast carcinoma, particularly in the area of molecular-targeted "target" therapies or immunotherapy. (Professor Guido Bellezza);
  • Study of the pathophysiology of atherosclerosis and its clinical and pre-clinical manifestations, study of dyslipidemia and traditional and emerging cardiovascular risk factors, in the field of Internal Medicine. (Dr. Massimo Raffaele Mannarino);
  • Research in the field of clinical microbiology, with particular reference to the diagnosis of sepsis and other infections with innovative technologies. Biomarkers. Epidemiology of infections by MDRO and emerging pathogens. Collaboration in several National networks for the surveillance of MDRO infections. Antimicrobial activity of new drugs against MDRO. MDRO, multi-drug resistant organisms. (Professor Antonella Mencacci);
  • Biological, clinical, and instrumental characterization of atherosclerotic-based cardiovascular disease, with application of integrated approaches of identifying predisposing pathologies (e.g., primary and secondary dyslipidemias) and risk factors of arterial wall damage; prognostic stratification and development of innovative diagnostic and therapeutic algorithms for atherosclerotic risk management. (Professor Matteo Pirro));
  • Biological and clinical characterization of the frail elderly at risk of falls, sarco-osteoporosis, fragility fractures. Understanding of biological, pathophysiological, and clinical-assistance determinants of health outcomes of the elderly, particularly the orthogeriatric elderly. Implementation of value-based organizational-care models and development of procedures for functional recovery and quality of life. (Professor Carmelinda Ruggiero)
  • Morphologic and functional characterization of preclinical vascular damage using computerized digital methods in order to quantify early morphologic alterations of the vessel wall (mid-intimal thickening; quantitative and qualitative characterization of atheromasic plaque), but also early functional alterations such as impaired flow-mediated vasoactivity and stiffness of large conduction arteries. (Professor Gaetano Vaudo);
  • Identification and validation of new biomarkers in neurological diseases and development of integrated algorithms for diagnosis and prognosis (Professor Lucilla Parnetti);
  • Study of the physiology and pathophysiology of motor control. Biomechanical analysis of muscle activations and mechanical stresses acting on specific joint structures in therapeutic exercise. (Professor Andrea Biscarini);
  • Study of neuronal and synaptic mechanisms in pathogenesis in late-onset and genetically based epilepsies (Professor Cinzia Costa);
  • Study of neuroplasticity mechanisms in experimental models of neurological diseases; identification of markers of neuro-immune interaction and neuro-inflammatory phenomena in central nervous system diseases (Professor Massimiliano Di Filippo);
  • New pharmacological approaches and molecular characterization of primary headaches (Professor Paola Sarchielli);
  • Effects of COVID-19 infection on mental health based on the national COMET (COvidMentalhEalth Trial) study; new determinants of mental health (role of noise, air and light pollution on mental illness; dysregulation of gut microbiota in mood disorders) (Professor Alfonso Antonio Vincenzo Tortorella);
  • Study of the mechanisms underlying neuronal communication and memorization. Multidisciplinary research approach that integrates electrophysiological techniques and behavioral tests applied to experimental murine, genetic and neurotoxic models, for the study of synaptopathy and inflammatory mechanisms associated with neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. (Professor Alessandro Tozzi);
  • Esophageal perforation. Surgical treatment of differentiated thyroid cancer infiltrating the airways. Surgical treatment of sternal metastasis from differentiated thyroid cancer. Surgical resection of the main tracheal carina. Pros and cons of the “Grillo’s anastomosis” in airway surgery. (Professor Francesco Puma);
  • Research in the field of cell transplants, in particular pancreatic islets immune-protected by semi-permeable membranes with the aim of correcting blood sugar levels and treating diabetes. Surgery for melanoma and soft tissue tumors (Professor Carlo Boselli);
  • Basic and translational research for the identification of diagnostic and prognostic biomarkers in uro-oncology (Professor Giovanni Cochetti);
  • Surgery of melanoma and soft tissue tumors. (Professor Piero Covarelli);
  • Laparoscopic and robotic surgery applied to urological pathologies of an oncological and functional nature; minimally invasive surgical treatments in endourology; basic and translational research in uro-oncology. (Professor Ettore Mearini, Professor Giovanni Cochetti);
  • Early diagnosis and treatment of hearing loss and prevention of communication disorders in children with deafness. Study of balance disorders linked to pathologies of the vestibular system. (Professor Giampietro Ricci);
  • CT and MRI of the chest and abdomen. Optimization of 3T body MRI protocols without gadolinium-based contrast material in oncology. Implementation and optimization of Split-Bolus multislice CT techniques in adult and pediatric cancer patients to reduce radiation dose. Usefulness of diffusion Magnetic Resonance imaging in cancer patients (Professor Michele Scialpi);
  • Functional genomics and leukemogenesis processes characterization in myeloid neoplasms; clonal evolution, identification of specific vulnerabilities and immune microenvironment characterization in acute myeloid leukemia (AML); high-throughput (HTS) drug screening and drug development/discovery in AML. (Professor Maria Paola Martelli);
  • Research and diagnostics in the field of oncohaematological diseases. Study of the bone marrow microenvironment in acute leukemia (Professor Stefano Ascani);
  • Chronic constipation: pathophysiology, diagnosis and treatment; Irritable bowel syndrome; Celiac disease; Chronic inflammatory bowel disease (Professor Gabrio Bassotti);
  • Lung cancer surgery (NSCLC). Identification of molecular markers for early diagnosis. EarlyDigit study (dPCR in early disease of NSLC patients). (Professor Lucio Cagini);
  • Biological characterization of acute B- and T-cell lymphoblastic leukemias with the application of integrated cytogenetic-molecular and functional approaches; identification of prognostic and predictive markers; design of diagnostic algorithms and study of molecular therapies. (Dr. Roberta La Starza);
  • Hematopoietic stem cell transplantation (HSCT) for hematological malignancies, pathogenesis and therapy of Graft-versus-Host-Disease, adoptive immunotherapy in HSCT, role of regulatory T cell. Development of innovative transplantation platforms, CAR-T cell therapy, treatment and immuno-monitoring. Development of novel cell therapies (Dr. Antonio Pierini);
  • Identification of pathogenetic mechanisms, predictive factors and translational medicine in chronic lymphatic leukemia. (Professor Paolo Sportoletti);
  • Chronic inflammatory skin disease (atopic dermatitis, psoriasis, GVHD); adverse drug reactions (clinical, pathogenesis, in vivo diagnosis). (Professor Luca Stingeni and Professor Katharina Hansel);
  • Identification and functional characterization of genetic lesions underlying leukemias and lymphomas, and their clinical translation in terms of precision diagnostics and targeted therapy. (Professor Enrico Tiacci);
  • Radiation treatments in conditioning for allogeneic hematopoietic stem cell transplantation (TBI and TMLI). Radiotherapy as a bridge treatment in patients who will receive CAR-T. Evaluation of the toxicity of radiation treatments. Graft-vs-Host Disease and correlation with treatment patterns radiotherapy (Professor Cynthia Aristei);
  • Prevention and treatment of odontostomatological and community dentistry diseases. Innovation in the management of dental pathologies in developmental age and application of psychological/pharmacological intervention techniques and minimally invasive methods (Professor Stefano Cianetti);
  • Functional Analysis, Fourier Analysis, Approximation Theory and their applications to digital image processing. Applications in medical diagnostics and engineering, imaging algorithms. (Professor Danilo Costarelli);
  • Lung cancer radiotherapy, combination of thoracic radiation and immunotherapy, and RT applications in hematology, including transplantation. Interdisciplinary research programs directed towards developing new RT-IO-TKI combinations in lung cancer and lymphomas, and radiation technical advancements, including next-generation IGRT and radiomics. (Professor Andrea R. Filippi);
  • Minimally invasive surgery applied to retinal and anterior segment pathologies; vascular and inflammatory pathologies of the retina. (Professor Tito Fiore) ;
  • Study of new radiotherapy techniques aimed at reducing the side effects of radiation treatments, with special attention directed toward the integration of molecularly targeted drugs and radiotherapy (Dr. Isabella Palumbo);
  • Medical applications of experimental particle physics, in particular in the field of nuclear medicine. Development of radio-guided surgery based on beta radiation. New approach to personalized dosimetry during radionuclide therapy treatments (Professor Francesco Collamati);
  • Characterization and treatment of patients with oligometastatic prostate cancer, radiomic analysis for the development of predictive models of response to cancer therapies, study of radio-immunotherapy combinations in clinical practice. (Dr. Andrea Lancia);