The PhD Course in Translational Medicine and Surgery, that aggregaates professors from different departments of the University of Perugia, is articulated into the following 2 curricula:
- TRANSLATIONAL MEDICINE
- TRANSLATIONAL SURGERY
Curriculum: TRANSLATIONAL MEDICINE
- Study of the physiopathological mechanisms of thrombosis and rationale for antithrombotic treatments
- Mechanisms for regulating vascular tone
- Regulation of neoangiogenesis and restenosis
- Study of the pathophysiology of hemorrhagic diseases
- Therapy of immunological thrombocytopenias
- Pathophysiology of erythrocyte deformability
- Pharmacology of platelet function inhibition
- Metabolism of lipid mediators in inflammatory cells
- Role of platelets in asthma and inflammation
- Membrane platelet receptors
- Pathophysiology of signal transduction in platelets
- Peripheral obstructive arteriopathy: pathophysiology and therapy
- Endothelial dysfunction
- Relationship between oxidative stress and lipid peroxidation in coronary heart disease
- Venous thromboembolism, pathophysiology and clinic
- Mechanisms of instability of the atherosclerotic plaque
- Physiological events related to metabolism, endocrine function and nutrition
- Pathophysiology of glucose metabolism in normal conditions and in type 1 and type 2 diabetics
- Pathophysiology of protein metabolism
- Physiopathology of adipose tissue: application of microdialysis techniques
- Pathophysiology of insulin-induced hypoglycemia
- Development of optimized therapeutic models in diabetes mellitus
- Role of physical activity in the prevention and treatment of diabetes mellitus and its complications
- Physiopathology of nutrition, with particular regard to obesity and eating disorders
- Diabetes and pregnancy: pathophysiology and optimized therapeutic models
- Diabetic foot: pathophysiology and skin graft therapy
- Pathophysiology of human reproduction; pathogenetic and clinical characterization of early menopause
- Autoimmune endocrine diseases: study of pathogenetic factors
- Neuroendocrine tumors: genetic, immunohistopathological and clinical characterization
- Epidemiology of diabetes mellitus and its micro and macroangiopathic complications; identification of risk factors
- Notions of bioengineering, biomaterials and biotechnology in the construction of vascular endoprostheses.
- Genetic research in some subgroups of hereditary aortic pathology.
- Microencapsulation techniques of pancreatic islets and other endocrine cells
- Biotechnologies of microencapsulation of endocrine cells in vascular districts
- Biotechnology and biomolecular methods on pancreatic stem cells
- Psychiatric aspects of eating disorders
- Doctor-patient relative communication
- Analysis of communication processes about the roles, purposes, contents of the interaction
- Psychogenic aspects in pain medicine
Curriculum: TRANSLATIONAL SURGERY
- Relationship between oxidative stress, reproduction and pathologies in pregnant women
- Reproduction of optimal nutrition in utero and growth pathology and metabolism of neonatal and adult ion and pathologies of pregnancy
- NGF and its receptors in oncology
- Analysis of the biomechanics of movement
- Development of minimally invasive reconstructive techniques in the arthroscopic and endoscopic field
- Tissue engineering for the regeneration of tendons and cartilages
- Search for CFTR gene rearrangements in subjects with azoospermia and CBAVD using the MLPA method
- Molecular study of the SHOX gene in subjects with short stature
- Evaluation of specific IgE variations for the different epitopes of grasses in patients with sublingual immunotherapy
- Study of techniques and materials of osteosynthesis in the musculoskeletal system.
- Study of techniques and materials in prosthetic surgery of the musculoskeletal system.
- Amputations and micro vascular reimplants: study of the biological aspects ed
- Invasive and non-invasive prenatal diagnosis. Identification, risk factors and prevention of recurrent abortion, preterm birth, gestational diabetes and preeclampsia.
- Perinatal origin of adult pathologies. New technologies and therapeutic strategies to improve the outcome of assisted reproduction and multiple pregnancies.
- Molecular genetic study for the evaluation of hereditary factors of male and female infertility
- Nutritional factors and reproduction
- Maternal-neonatal outcome in women of advanced age
- Identification of early ultrasound and humoral markers in hypertension in pregnancy
- The vaginal surgical approach: feasibility study for new gynecological procedures
- Study for the evaluation of clinical risk, quality of health documentation, protection of disability, work suitability.
- Necropsy medicine: sudden cardiac death, cases of particular medical-forensic interest.
- Forensic medical toxicology and clinical drug addiction toxicology: qualitative and quantitative determinations of narcotic drugs - psychotropic and doping-effect substances in biological matrices;
- PET-CT and SPECT-CT oncology imaging and radiometabolic / RIT therapy.
- Prospective study to evaluate the clinical and prognostic significance of vascular endothelial growth factor (VEGF) in neoplastic pathologies of surgical interest.
- Prospective study to evaluate the clinical and prognostic significance of the endothelial progenitor cell (EPC) assay in neoplastic pathologies of surgical interest.
- Study and clinical application of endovascular technologies and methods for the minimally invasive treatment of complex vascular diseases (aortic, epiaortic trunks, peripheral arteriopathies).
- Physiopathology and clinical pathology of vascular diseases of surgical interest.
- Genetic aspects and translational research on gastric neoplasms.
- Treatment of peritoneal carcinosis with intraoperative intraperitoneal chemohyperthermia.
- Study of the biomolecular mechanism of peritoneal carcinogenesis.
- Faecal incontinence.
- Peri-operative nutritional status in the cancer patient.
- Translational study on tissue regeneration of myocardial and vascular tissue using stem cells.
- Imaging evaluation of stress forces in the dilated pathology of the Large Vessels
- Evaluation of robotic techniques in the manipulation and navigation of endovascular implantable systems.
- Nuclear receptors in the pathophysiology of the liver and gastrointestinal tract, with reference to metabolic diseases of the liver and chronic intestinal inflammatory diseases.
- Molecular biology of the FXR, PXR and CAR receptor in oncological pathology of the liver and gastrointestinal tract. Clinical research on original surgical techniques: Development of minimally invasive reconstructive techniques for pelvic organ prolapse.
- Medical and surgical andrology
- Basic research on tissue bioengineering in urology.
- Research in functional urology: use of botulinum toxin in urology, study of receptors and neurotransmitters in the bladder: new potential chemo-immunotherapeutic agents.
- Study of oxidative stress in erectile dysfunctions
- Basic research in the field of chronic pelvic pain
- Diagnostic and prognostic biomarkers in urological and endocrine oncology.
- Development of biotechnologies for minimally invasive surgical therapy.
- Neurotrophic factors in prostate cancer.
- Study on the modalities of autologous transplantation of parathyroid cells in vitro,
- Genetic and proteomic analysis of thyroid and urological neoplasms.